Quality assessment of nine paracetamol 500 mg tablet brands marketed in Saudi Arabia.

ABSTRACT:

Objective

To evaluate in-vitro quality of paracetamol 500 mg tablet brands marketed in Saudi Arabia.

Results

Two reference (R1 and R2) and seven generic (G1-G7) brands were commercially available. Four brands were single-drug, containing paracetamol only (R1, G1-G3) and five contained additional active ingredients (R2, G4-G7). All brands were immediate-release. Weight variation (n = 20, range as percent difference from mean), active substance content (n = 20, mean (SD) as percent difference from label), breaking force (n = 10, mean (SD)), and friability (n = 20, as percent weight loss) ranged from 97 to 102%, 96.1% (2.9%) to 99.8% (1.1%), 9.9 (0.4) to 21.0 (0.9) kg, and 0.017% to 0.809%, respectively. Disintegration (water medium) time (n = 6, minute: second) ranged from 02:

SUBMITTER: AlSwayeh R 

PROVIDER: S-EPMC8247153 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature