Down-regulation of BCL2L13 renders poor prognosis in clear cell and papillary renal cell carcinoma.

ABSTRACT:

Background

BCL2L13 belongs to the BCL2 super family, with its protein product exhibits capacity of apoptosis-mediating in diversified cell lines. Previous studies have shown that BCL2L13 has functional consequence in several tumor types, including ALL and GBM, however, its function in kidney cancer remains as yet unclearly.

Methods

Multiple web-based portals were employed to analyze the effect of BCL2L13 in kidney cancer using the data from TCGA database. Functional enrichment analysis and hubs of BCL2L13 co-expressed genes in clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC) were carried out on Cytoscape. Evaluation of BCL2L13 protein level was accomplished through immunohistochemistry on paraffin embedded renal cancer tissue sections. Wester

SUBMITTER: Meng F 

PROVIDER: S-EPMC8247248 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature