Monocyte subsets predict mortality after cardiac arrest.

ABSTRACT: After successful cardiopulmonary resuscitation (CPR), many patients show signs of an overactive immune activation. Monocytes are a heterogeneous cell population that can be distinguished into 3 subsets by flow cytometry (classical monocytes [CM: CD14⁺⁺ CD16^- ], intermediate monocytes [IM: CD14⁺⁺ CD16⁺ CCR2⁺ ] and non-classical monocytes [NCM: CD14⁺ CD16⁺⁺ CCR2^- ]). Fifty-three patients admitted to the medical intensive care unit (ICU) after cardiac arrest were included. Blood was taken on admission and after 72 h. The primary endpoint of this study was survival at 6 months and the secondary endpoint was neurological outcome as determined by cerebral performance category (CPC)-score at 6 months. Median a

SUBMITTER: Krychtiuk KA 

PROVIDER: S-EPMC8247267 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature