Deficit of Cross-Frequency Integration in Mild Cognitive Impairment and Alzheimer's Disease: A Multilayer Network Approach.

ABSTRACT:

Background

Studies at specific frequencies have shown abnormalities in brain functional networks among mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients. Previous studies have failed to take into account the possibility that optimal cognitive integration requires interactions between different frequency bands.

Purpose

To study whether there is abnormal cross-frequency integration in patients' brains during disease progression.

Study type

Retrospective.

Population

Forty-six normal control (NC), 85 patients with MCI, and 31 patients with AD.

Field strength/sequence

3T.

Assessment

Multilayer network models were constructed for NC, MCI, and AD, and multilayer participation coefficient (MPC) was used to study the changes of the inte

SUBMITTER: Wang X 

PROVIDER: S-EPMC8247269 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature