Synthesis of "Nereid," a new phenol-free detergent to replace Triton X-100 in virus inactivation.

ABSTRACT: In the 1980s, virus inactivation steps were implemented into the manufacturing of biopharmaceuticals in response to earlier unforeseen virus transmissions. The most effective inactivation process for lipid-enveloped viruses is the treatment by a combination of detergents, often including Triton X-100 (TX-100). Based on recent environmental concerns, the use of TX-100 in Europe will be ultimately banned, which forces the pharmaceutical industry, among others, to switch to an environmentally friendly alternative detergent with fully equivalent virus inactivation performance such as TX-100. In this study, a structure-activity relationship study was conducted that ultimately led to the synthesis of several new detergents. One of them, named "Nereid," displayed inactivation activity fully equiv

SUBMITTER: Farcet JB 

PROVIDER: S-EPMC8247325 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature