Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine.

ABSTRACT:

Aims

Carbamazepine can cause hypersensitivity reactions in ~10% of patients. An immunogenic effect can be produced by the electrophilic 10,11-epoxide metabolite but not by carbamazepine. Hypothetically, certain single nucleotide polymorphisms might increase the formation of immunogenic metabolites, leading ultimately to hypersensitivity reactions. This study explores the role of clinical and genetic factors in the pharmacokinetics (PK) of carbamazepine and 3 metabolites known to be chemically reactive or formed through reactive intermediates.

Methods

A combination of rich and sparse PK samples were collected from healthy volunteers and epilepsy patients. All subjects were genotyped for 20 single nucleotide polymorphisms in 11 genes known to be involved in the metabolism or t

SUBMITTER: Yip VLM 

PROVIDER: S-EPMC8247401 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature