Butyrate as a bioactive human milk protective component against food allergy.

ABSTRACT:

Background

Food allergy (FA) is a growing health problem worldwide. Effective strategies are advocated to limit the disease burden. Human milk (HM) could be considered as a protective factor against FA, but its mechanisms remain unclear. Butyrate is a gut microbiota-derived metabolite able to exert several immunomodulatory functions. We aimed to define the butyrate concentration in HM, and to see whether the butyrate concentration detected in HM is able to modulate the mechanisms of immune tolerance.

Methods

HM butyrate concentration from 109 healthy women was assessed by GS-MS. The effect of HM butyrate on tolerogenic mechanisms was assessed in in vivo and in vitro models.

Results

The median butyrate concentration in mature HM was 0.75 mM. This butyrate concentration

SUBMITTER: Paparo L 

PROVIDER: S-EPMC8247419 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature