Multimorbidity burden and dementia risk in older adults: The role of inflammation and genetics.

ABSTRACT:

Introduction

We investigate dementia risk in older adults with different disease patterns and explore the role of inflammation and apolipoprotein E (APOE) genotype.

Methods

A total of 2,478 dementia-free participants with two or more chronic diseases (ie, multimorbidity) part of the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) were grouped according to their multimorbidity patterns and followed to detect clinical dementia. The potential modifier effect of C-reactive protein (CRP) and apolipoprotein E (APOE) genotype was tested through stratified analyses.

Results

People with neuropsychiatric, cardiovascular, and sensory impairment/cancer multimorbidity had increased hazards for dementia compared to the unspecific (Hazard ration (HR) 1.66, 95% confi

SUBMITTER: Grande G 

PROVIDER: S-EPMC8247430 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature