Neuromuscular ultrasound for taxane peripheral neuropathy in breast cancer.

ABSTRACT:

Background

Our study aim was to evaluate neuromuscular ultrasound (NMUS) for the assessment of taxane chemotherapy-induced peripheral neuropathy (CIPN), the dose-limiting toxicity of this agent.

Methods

This cross-sectional study of breast cancer patients with taxane CIPN measured nerve cross-sectional area (CSA) by NMUS and compared with healthy historical controls. Correlations were determined between CSA and symptom scale, nerve conduction studies, and intraepidermal nerve fiber density (IENFD).

Results

A total of 20 participants reported moderate CIPN symptoms at a median of 3.8 months following the last taxane dose. Sural nerve CSA was 1.2 mm² smaller than healthy controls (P ≤ .01). Older age and time since taxane were associated with smaller sural ne

SUBMITTER: Lycan TW 

PROVIDER: S-EPMC8247453 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature