Genetic Risk Factors for CVD in Type 1 Diabetes: The DCCT/EDIC Study.

ABSTRACT:

Objective

The role of genetic factors in the risk of cardiovascular disease (CVD) for patients with type 1 diabetes (T1D) remains unknown. We therefore examined whether previously identified genetic factors for coronary artery disease (CAD) are associated with the risk of CVD above and beyond established demographic and clinical factors in the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) study.

Research design and methods

Polygenic risk scores (PRS) and individual genetic variants identified in previous studies were obtained from genome-wide genotyping performed in 1,371 DCCT/EDIC participants. Two composite CVD outcomes were considered: major adverse cardiovascular events (MACE) (CVD death or nonfatal myocar

SUBMITTER: Bebu I 

PROVIDER: S-EPMC8247524 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature