Oncogenic Mechanisms and Therapeutic Targeting of Metabolism in Leukemia and Lymphoma.

ABSTRACT: Leukemias and lymphomas acquire the capacity for unrestrained cell growth and proliferation in conjunction with loss of responsiveness to molecular programs that promote terminal differentiation. Malignant cells generate the building blocks required for rapid cell division through both increased acquisition of nutrients from the environment and reprogrammed intermediary metabolism to shunt these molecules into producing the protein, lipids, and nucleic acids that comprise cell biomass. These accelerated metabolic processes require energy in the form of ATP and reducing equivalents in the form of NADPH, which power biosynthetic reactions and buffer oxidative stress encountered by the metabolically active cancer cell. Cancer-associated metabolic alterations can also promote accumulation or d

SUBMITTER: Stahl M 

PROVIDER: S-EPMC8247556 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature