Junctional ER Organization Affects Mechanotransduction at Cadherin-Mediated Adhesions.

ABSTRACT: Cadherin-mediated adhesions (also known as adherens junctions) are adhesive complexes that connect neighboring cells in a tissue. While the role of the actin cytoskeleton in withstanding tension at these sites of contact is well documented, little is known about the involvement of microtubules and the associated endoplasmic reticulum (ER) network in cadherin mechanotransduction. Therefore, we investigated how the organization of ER extensions in close proximity of cadherin-mediated adhesions can affect such complexes, and vice versa. Here, we show that the extension of the ER to cadherin-mediated adhesions is tension dependent and appears to be cadherin-type specific. Furthermore, the different structural organization of the ER/microtubule network seems to affect the localization of ER-bou

SUBMITTER: Joy-Immediato M 

PROVIDER: S-EPMC8247578 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature