Mapping Salivary Proteases in Sjogren's Syndrome Patients Reveals Overexpression of Dipeptidyl Peptidase-4/CD26.

ABSTRACT: Sjögren's Syndrome (SS) is an autoimmune exocrinopathy characterized by the progressive damage of salivary and lacrimal glands associated with lymphocytic infiltration. Identifying new non-invasive biomarkers for SS diagnosis remains a challenge, and alterations in saliva composition reported in patients turn this fluid into a source of potential biomarkers. Among these, proteases are promising candidates since they are involved in several key physio-pathological processes. This study evaluated differentially expressed proteases in SS individuals' saliva using synthetic fluorogenic substrates, zymography, ELISA, and proteomic approaches. Here we reported, for the first time, increased activity of the serine protease dipeptidyl peptidase-4/CD26 (DPP4/CD26) in pSS saliva, the expression leve

SUBMITTER: Garreto L 

PROVIDER: S-EPMC8247581 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature