A hybrid parametric and empirical likelihood model for evaluating interactions in case-control Studies.

ABSTRACT: The case-control design provides an effective way to collect covariate information conditioning on subjects' disease status. The standard logistic regression model can be used to model the interaction between two covariates under such a design, but the prospective logistic regression method might not be the most efficient one when certain appropriate constraints can be imposed on the covariate distribution. We develop a hybrid approach for the statistical inference of the interaction under the case-control design. We use a parametric model to characterize the conditional distribution of one covariate given the another covariate in the control population, while leaving the distribution of the later covariate to be fully nonparametric. A maximum hybrid parametric and empirical likelihood met

SUBMITTER: Qin J 

PROVIDER: S-EPMC8247649 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature