Oncological Effects and Prognostic Value of AMAP1 in Gastric Cancer.

ABSTRACT:

Purpose

We examined the diagnostic significance, prognostic value, and potential function of AMAP1 in gastric cancer (GC).

Methods

Comprehensive bioinformatic analysis was conducted to investigate differential expression of AMAP1 mRNA and protein in GC. Meta-analyses were utilized to determine the overall prognostic correlation of AMAP1 mRNA in patients with GC. A panel of vitro assays was applied to assess target microRNA and AMAP1 protein in GC cell lines and tissues, respectively.

Results

AMAP1 mRNA and protein levels were upregulated in GC specimens, compared to matched normal tissues. AMAP1 mRNA exhibited promising results regarding differential diagnosis of GC and normal tissue. Meta-analysis based on the TCGA and GEO databases revealed that high AMAP1 mRNA abun

SUBMITTER: Li J 

PROVIDER: S-EPMC8247770 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature