Tracheal anomalies associated with Down syndrome: A systematic review.

ABSTRACT:

Introduction

Airway anomalies are accountable for a substantial part of morbidity and mortality in children with Down syndrome (DS). Although tracheal anomalies occur more often in DS children, a structured overview on the topic is lacking. We systematically reviewed the characteristics of tracheal anomalies in DS children.

Methods

A MEDLINE and EMBASE search for DS and tracheal anomalies was performed. Tracheal anomalies included tracheal stenosis, complete tracheal ring deformity (CTRD), tracheal bronchus, tracheomalacia, tracheal web, tracheal agenesis or atresia, laryngotracheoesophageal cleft type 3 or 4, trachea sleeve, and absent tracheal rings.

Results

Fifty-nine articles were included. The trachea of DS children is significantly smaller than non-DS children.

SUBMITTER: Fockens MM 

PROVIDER: S-EPMC8247859 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature