Chronic migraine: Genetics or environment?

ABSTRACT:

Background

The transition from episodic migraine to chronic migraine, migraine chronification, is usually a gradual process, which involves multiple risk factors. To date, studies of the genetic risk factors for chronic migraine have focused primarily on candidate-gene approaches using healthy individuals as controls.

Aims and methods

In this study, we used a large cohort of migraine families and unrelated migraine patients (n > 2200) with supporting genotype and whole-genome sequencing data. We evaluated whether there are any genetic variants, common or rare, with a specific association to chronic migraine compared with episodic migraine.

Results

We found no aggregation of chronic migraine in families with a clustering of migraine. No specific rare variants gave rise

SUBMITTER: Chalmer MA 

PROVIDER: S-EPMC8247872 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature