Non-neutralizing antibodies protect against chronic LCMV infection by promoting infection of inflammatory monocytes in mice.

ABSTRACT: Antibodies play an important role in host defense against microorganisms. Besides direct microbicidal activities, antibodies can also provide indirect protection via crosstalk to constituents of the adaptive immune system. Similar to many human chronic viral infections, persistence of Lymphocytic choriomeningitis virus (LCMV) is associated with compromised T- and B-cell responses. The administration of virus-specific non-neutralizing antibodies (nnAbs) prior to LCMV infection protects against the establishment of chronic infection. Here, we show that LCMV-specific nnAbs bind preferentially Ly6C^hi inflammatory monocytes (IMs), promote their infection in an Fc-receptor independent way, and support acquisition of APC properties. By constituting additional T-cell priming opportuniti

SUBMITTER: Stoycheva D 

PROVIDER: S-EPMC8247883 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature