The APOE ε4 allele in relation to pre- and postsurgical cognitive functioning of patients with primary brain tumors.

ABSTRACT:

Background

Recent studies suggest a relationship between the APOE ε4 allele and cognitive outcome in patients treated for malignant brain tumors. Still, longitudinal investigations that include a pretreatment cognitive assessment are lacking and APOE's effects in patients with benign tumors are understudied. This study investigated presurgical cognitive performance and postsurgical change in ε4-carrying and non-carrying patients with glioma and meningioma.

Methods

Neuropsychological test scores (CNS Vital Signs battery [seven measures], Digit Span Forward/Backward, Letter Fluency test) were obtained as part of a prospective study in which patients with meningioma and glioma underwent cognitive assessment 1 day before (T0, n = 505) and 3 (T3, n = 418) and 12 months after (T12

SUBMITTER: Butterbrod E 

PROVIDER: S-EPMC8247965 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature