Dipyrrinato-Iridium(III) Complexes for Application in Photodynamic Therapy and Antimicrobial Photodynamic Inactivation.

ABSTRACT: The generation of bio-targetable photosensitizers is of utmost importance to the emerging field of photodynamic therapy and antimicrobial (photo-)therapy. A synthetic strategy is presented in which chelating dipyrrin moieties are used to enhance the known photoactivity of iridium(III) metal complexes. Formed complexes can thus be functionalized in a facile manner with a range of targeting groups at their chemically active reaction sites. Dipyrrins with N- and O-substituents afforded (dipy)iridium(III) complexes via complexation with the respective Cp*-iridium(III) and ppy-iridium(III) precursors (dipy=dipyrrinato, Cp*=pentamethyl-η⁵ -cyclopentadienyl, ppy=2-phenylpyridyl). Similarly, electron-deficient [Ir^III (dipy)(ppy)₂ ] complexes could be used for post-

SUBMITTER: Hohlfeld BF 

PROVIDER: S-EPMC8248005 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature