Reorganization of brain structural networks in aging: A longitudinal study.

ABSTRACT: Normal aging is characterized by structural and functional changes in the brain contributing to cognitive decline. Structural connectivity (SC) describes the anatomical backbone linking distinct functional subunits of the brain and disruption of this communication is thought to be one of the potential contributors for the age-related deterioration observed in cognition. Several studies already explored brain network's reorganization during aging, but most focused on average connectivity of the whole-brain or in specific networks, such as the resting-state networks. Here, we aimed to characterize longitudinal changes of white matter (WM) structural brain networks, through the identification of sub-networks with significantly altered connectivity along time. Then, we tested associations betw

SUBMITTER: Coelho A 

PROVIDER: S-EPMC8248023 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature