A model for interrogating the clinico-radiological paradox in multiple sclerosis: Internuclear ophthalmoplegia.

ABSTRACT:

Background and purpose

The clinico-radiological paradox in multiple sclerosis (MS) is well recognized, relevant and yet poorly understood. The suitability of an in vivo model for the clinico-radiological paradox was tested, using internuclear ophthalmoplegia (INO) and the medial longitudinal fasciculus (MLF).

Methods

In this cross-sectional study lesions of the MLF were rated by an experienced MS neuroradiologist blinded to all other information. The presence of an INO was objectively determined by a validated infrared oculography protocol (DEMoNS). Clinical information, including the National Eye Institute Visual Function Questionnaire, was obtained.

Results

This study included 202 patients with MS. The clinico-radiological paradox occurred in 50 patients (25%). This

SUBMITTER: Nij Bijvank JA 

PROVIDER: S-EPMC8248033 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature