Ontology highlight
ABSTRACT:
SUBMITTER: Mo D
PROVIDER: S-EPMC8248075 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Mo Dongliang D Zhu Hai H Wang Jun J Hao Haibang H Guo Yuming Y Wang Jiaojiao J Han Xu X Zou Liangfeng L Li Zhongwan Z Yao Hua H Zhu Jinsong J Zhou Junma J Peng Yong Y Li Jian J Meng Kun K
European journal of immunology 20210209 4
Icaritin, a small molecule currently being investigated in phase III clinical trials in China (NCT03236636 and NCT03236649) for treatment of advanced hepatocellular carcinoma (HCC), is a prenylflavonoid derivative obtained from the Epimedium genus. Previously, it was found that Icaritin decreased the expression of PD-L1, but its direct molecular targets and the underlying mechanisms have not been identified. In this study, we report the identification of IKK-α as the protein target of Icaritin b ...[more]