Genetic effects of allergen-specific IgE levels on exhaled nitric oxide in schoolchildren with asthma: The STOPPA twin study.

ABSTRACT:

Background

Exhaled nitric oxide and blood eosinophils are clinical asthma T-helper type 2 markers in use. Immunoglobulin E (IgE) is often involved in the inflammation associated with atopic asthma. The effect of both blood eosinophils and allergen-specific IgE on exhaled nitric oxide levels is not completely understood. Twin-design studies can improve understanding of the underlying contribution of genetically and/or environmentally driven inflammation markers in asthma. Our aim was to disentangle the covariance between asthma and exhaled nitric oxide into genetic and environmental contributions that can account for inflammation markers in a paediatric population.

Methods

This population-based, cross-sectional twin study enrolled 612 monozygotic (MZ) and same-sex dizygotic (

SUBMITTER: Hedman AM 

PROVIDER: S-EPMC8248142 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature