Pregnancy outcome after first trimester exposure to domperidone-An observational cohort study.

ABSTRACT:

Aim

To assess the teratogenic risk of domperidone by comparing the incidence of major malformation with domperidone to a control.

Methods

Pregnancy outcome data were obtained for women at two Japanese facilities that provide counseling on drug use during pregnancy between April 1988 and December 2017. The incidence of major malformation was calculated among infants born to women taking domperidone (n = 519), nonteratogenic drugs (control, n = 1673), or metoclopramide (reference, n = 241) during the first trimester of pregnancy. Using the control group as reference, the crude odds ratio (OR) of the incidence of major malformation in the domperidone and metoclopramide groups was calculated using univariable logistic regression analysis. Adjusted OR was also calculated using mu

SUBMITTER: Hishinuma K 

PROVIDER: S-EPMC8248151 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature