Autonomous TGFβ signaling induces phenotypic variation in human acute myeloid leukemia.

ABSTRACT: Heterogeneity of leukemia stem cells (LSCs) is involved in their collective chemoresistance. To eradicate LSCs, it is necessary to understand the mechanisms underlying their heterogeneity. Here, we aimed to identify signals responsible for heterogeneity and variation of LSCs in human acute myeloid leukemia (AML). Monitoring expression levels of endothelial cell-selective adhesion molecule (ESAM), a hematopoietic stem cell-related marker, was useful to detect the plasticity of AML cells. While healthy human hematopoietic stem/progenitor cells robustly expressed ESAM, AML cells exhibited heterogeneous ESAM expression. Interestingly, ESAM^- and ESAM⁺ leukemia cells obtained from AML patients were mutually interconvertible in culture. KG1a and CMK, human AML clones, also r

SUBMITTER: Shingai Y 

PROVIDER: S-EPMC8248163 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature