Cytokines and Gaucher Biomarkers in Glucocerebrosidase Carriers with and Without Parkinson Disease.

ABSTRACT:

Background

Homozygous and compound heterozygous variants in glucocerebrosidase (GBA) can cause Gaucher disease (GD), whereas heterozygous variants increase the risk of developing Parkinson's disease (PD). GD patients display altered peripheral immune proteins. However, it is unknown if these are altered in GBA carriers with PD.

Objectives

To determine whether plasma cytokines and immune biomarkers associated with GD are also altered in GBA carriers with or without PD.

Methods

Inflammatory cytokines and established GD biomarkers, ferritin, CD162, CCL18, and chitotriosidase (28 biomarkers) were measured in GBA pathogenic variant carriers with (n = 135) and without (n = 83) PD, and non-carriers with (n = 75) and without PD (n = 77).

Results

PD patients with bialle

SUBMITTER: Galper J 

PROVIDER: S-EPMC8248172 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature