Geometric contour variation in clinical target volume of axillary lymph nodes in breast cancer radiotherapy: an AIRO multi-institutional study.

ABSTRACT:

Objectives

To determine interobserver variability in axillary nodal contouring in breast cancer (BC) radiotherapy (RT) by comparing the clinical target volume of participating single centres (SC-CTV) with a gold-standard CTV (GS-CTV).

Methods

The GS-CTV of three patients (P1, P2, P3) with increasing complexity was created in DICOM format from the median contour of axillary CTVs drawn by BC experts, validated using the simultaneous truth and performance-level estimation and peer-reviewed. GS-CTVs were compared with the correspondent SC-CTVs drawn by radiation oncologists, using validated metrics and a total score (TS) integrating all of them.

Results

Eighteen RT centres participated in the study. Comparative analyses revealed that, on average, the SC-CTVs were smaller

SUBMITTER: Leonardi MC 

PROVIDER: S-EPMC8248216 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature