Clinical Manifestations and Outcomes in Immunocompetent and Immunocompromised Patients With Blastomycosis.

ABSTRACT:

Background

Blastomyces is a dimorphic fungus that infects persons with or without underlying immunocompromise. To date, no study has compared the clinical features and outcomes of blastomycosis between immunocompromised and immunocompetent persons.

Methods

A retrospective study of adult patients with proven blastomycosis from 2004-2016 was conducted at the University of Wisconsin. Epidemiology, clinical features, and outcomes were analyzed among solid-organ transplantation (SOT) recipients, persons with non-SOT immunocompromise (non-SOT IC), and persons with no immunocompromise (NIC).

Results

A total of 106 cases met the inclusion criteria including 74 NIC, 19 SOT, and 13 non-SOT IC (malignancy, HIV/AIDS, idiopathic CD4+ lymphopenia). The majority of patients (61.3%)

SUBMITTER: McBride JA 

PROVIDER: S-EPMC8248256 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature