Medulloblastoma recurrence and metastatic spread are independent of colony-stimulating factor 1 receptor signaling and macrophage survival.

ABSTRACT:

Purpose

Tumor infiltration by immunosuppressive myeloid cells or tumor-associated macrophages (TAMs) contributes to tumor progression and metastasis. In contrast to their adult counterparts, higher TAM signatures do not correlate with aggressive tumor behavior in pediatric brain tumors. While prominent TAM infiltrates exist before and after radiation, the degree to which irradiated macrophages and microglia support progression or leptomeningeal metastasis remains unclear. Patients with medulloblastoma often present with distant metastases and tumor recurrence is largely incurable, making them prime candidates for the study of novel approaches to prevent neuroaxis dissemination and recurrence.

Methods

Macrophage depletion was achieved using CSF-1 receptor inhibitors (CSF-1Ri)

SUBMITTER: Crotty EE 

PROVIDER: S-EPMC8248272 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature