Discovery of melanin-concentrating hormone receptor 1 in brown adipose tissue.

ABSTRACT: Although extensive research on brown adipose tissue (BAT) has stimulated optimism in the battle against obesity and diabetes, BAT physiology and organ crosstalk are not fully understood. Besides BAT, melanin-concentrating hormone (MCH) and its receptor (MCHR1) play an important role in energy homeostasis. Because of the link between hypothalamic MCH neurons and sympathetic BAT activation via β-adrenoceptors, we investigated the expression and physiological role of the MCHR1 in BAT. MCHR1 was detected in rodent and human BAT with RT-qPCR and western blot analyses. In vivo imaging in rats used the glucose analog [¹⁸ F]FDG and the MCHR1-tracer [¹¹ C]SNAP-7941. We found that the β3-adrenoceptor (ADRB3) agonist CL316,243 increased [¹¹ C]SNAP-7941 uptake in BAT.

SUBMITTER: Philippe C 

PROVIDER: S-EPMC8248337 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature