Type 1 Diabetes and the HLA Region: Genetic Association Besides Classical HLA Class II Genes.

ABSTRACT: Type 1 diabetes is an autoimmune disease with rising incidence in high-income countries. Genetic and environmental predisposing factors contribute to the etiology of the disease, although their interaction is not sufficiently understood to allow for preventive action. Strongest known associations with genetic variation map to classical HLA class II genes. Because of its genetic complexity, the HLA region has been under-represented in genome-wide association studies, having potentially hindered the identification of relevant associations underlying the etiology of the disease. Here, we performed a comprehensive HLA-wide genetic association analysis of type 1 diabetes including multi-allelic and rare variants. We used high-density whole-exome sequencing data of the HLA region in the large UK

SUBMITTER: Sticht J 

PROVIDER: S-EPMC8248358 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature