Visual Dysfunction Predicts Cognitive Impairment and White Matter Degeneration in Parkinson's Disease.

ABSTRACT:

Background

Visual dysfunction predicts dementia in Parkinson's disease (PD), but whether this translates to structural change is not known. The objectives of this study were to identify longitudinal white matter changes in patients with Parkinson's disease and low visual function and also in those who developed mild cognitive impairment.

Methods

We used fixel-based analysis to examine longitudinal white matter change in PD. Diffusion MRI and clinical assessments were performed in 77 patients at baseline (22 low visual function/55 intact vision and 13 PD-mild cognitive impairment/51 normal cognition) and 25 controls and again after 18 months. We compared microstructural changes in fiber density, macrostructural changes in fiber bundle cross-section and combined fiber density

SUBMITTER: Zarkali A 

PROVIDER: S-EPMC8248368 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature