The Parkinson's Disease DNA Variant Browser.

ABSTRACT:

Background

Parkinson's disease (PD) is a genetically complex neurodegenerative disease with ~20 genes known to contain mutations that cause PD or atypical parkinsonism. Large-scale next-generation sequencing projects have revolutionized genomics research. Applying these data to PD, many genes have been reported to contain putative disease-causing mutations. In most instances, however, the results remain quite limited and rather preliminary. Our aim was to assist researchers on their search for PD-risk genes and variant candidates with an easily accessible and open summary-level genomic data browser for the PD research community.

Methods

Sequencing and imputed genotype data were obtained from multiple sources and harmonized and aggregated.

Results

In total we included

SUBMITTER: Kim JJ 

PROVIDER: S-EPMC8248407 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature