Validation of an international prediction model including the Oxford classification in Korean patients with IgA nephropathy.

ABSTRACT:

Background

Recently, a new international risk prediction model including the Oxford classification was published which was validated in a large multi-ethnic cohort. Therefore, we aimed to validate this risk prediction model in Korean patients with IgA nephropathy.

Methods

This retrospective cohort study was conducted with 545 patients who diagnosed IgA nephropathy with renal biopsy in three medical centers. The primary outcome was defined as a reduction in estimated glomerular filtration rate (eGFR) of >50% or incident end-stage renal disease (ESRD). Continuous net reclassification improvement (cNRI) and integrated discrimination improvement (IDI) were used to validate models.

Results

During the median 3.6 years of follow-up period, 53 (9.7%) renal events occurred. In

SUBMITTER: Hwang D 

PROVIDER: S-EPMC8248408 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature