Higher Concentration of Plasma Glial Fibrillary Acidic Protein in Wilson Disease Patients with Neurological Manifestations.

ABSTRACT:

Background

Wilson disease is a rare, disabling, neurological genetic disease. Biomarkers of brain damage are less well developed.

Objective

The aim of this study was to evaluate the utility of plasma glial fibrillary acidic protein as a biomarker for neurological involvement in patients with Wilson disease.

Methods

This prospective cross-observational study compared plasma glial fibrillary acidic protein concentration among different subtypes of patients with Wilson disease and healthy control subjects. Plasma glial fibrillary acidic protein levels were measured in 94 patients and 25 healthy control subjects. Patients were divided into two subtypes: patients with neurological manifestations (n = 74) or hepatic manifestations (n = 20).

Results

Median levels of p

SUBMITTER: Lin J 

PROVIDER: S-EPMC8248415 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature