Protection of liver sinusoids by intravenous administration of human Muse cells in a rat extra-small partial liver transplantation model.

ABSTRACT: Small-for-size syndrome (SFSS) has a poor prognosis due to excessive shear stress and sinusoidal microcirculatory disturbances in the acute phase after living-donor liver transplantation (LDLT). Multilineage-differentiating stress enduring (Muse) cells are reparative stem cells found in various tissues and currently under clinical trials. These cells selectively home to damaged sites via the sphingosine-1-phosphate (S1P)-S1P receptor 2 system and repair damaged tissue by pleiotropic effects, including tissue protection and damaged/apoptotic cell replacement by differentiating into tissue-constituent cells. The effects of intravenously administered human bone marrow-Muse cells and -mesenchymal stem cells (MSCs) (4 × 10⁵ ) on liver sinusoidal endothelial cells (LSECs) were examine

SUBMITTER: Shono Y 

PROVIDER: S-EPMC8248424 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature