Integrated Analysis of Genomic and Immunological Features in Lung Adenocarcinoma With Micropapillary Component.

ABSTRACT:

Background

Micropapillary adenocarcinoma is one of the most aggressive histologic subtypes of lung adenocarcinoma (LADC), and even a minor proportion of micropapillary component (MPC) within the LADC could contribute to poor prognosis. Comprehensive analysis of genetic and immunological features of LADC with different percentages of MPC would help better understand cancer biology of this LADC subtype and direct future treatments.

Methods

We performed next-generation sequencing (NGS) for a discovery cohort of 43 LADC patients whose tumors were micro-dissected to separate MPC and non-MPC lesions and a reference cohort of 113 LADC patients. MPC-enriched genetic alterations that were detected in the discovery cohort were then confirmed using a validation cohort of 183 LADC patie

SUBMITTER: Zhang S 

PROVIDER: S-EPMC8248503 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature