S100a9 Protects Male Lupus-Prone NZBWF1 Mice From Disease Development.

ABSTRACT: Systemic lupus erythematosus (SLE) is an autoimmune disorder disproportionally affecting women. A similar sex difference exists in the murine New Zealand Black/White hybrid model (NZBWF1) of SLE with all females, but only 30-40% of males, developing disease within the first year of life. Myeloid-derived suppressor cells (MDSCs) are prominent in NZBWF1 males and while depletion of these cells in males, but not females, promotes disease development, the mechanism of suppression remains unknown. S100a9, expressed by neutrophils and MDSCs, has previously been shown to exert immunosuppressive functions in cancer and inflammation. Here we investigated if S100a9 exerts immunosuppressive functions in NZBWF1 male and female mice. S100a9 ^+/+, S100a9 ^+/- and S10

SUBMITTER: Davison LM 

PROVIDER: S-EPMC8248531 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature