Helicobacter pylori-Induced Heparanase Promotes H. pylori Colonization and Gastritis.

ABSTRACT: Chronic gastritis caused by Helicobacter pylori (H. pylori) infection has been widely recognized as the most important risk factor for gastric cancer. Analysis of the interaction between the key participants in gastric mucosal immunity and H. pylori infection is expected to provide important insights for the treatment of chronic gastritis and the prevention of gastric cancer. Heparanase is an endoglycosidase that degrades heparan sulfate, resulting in remodeling of the extracellular matrix thereby facilitating the extravasation and migration of immune cells towards sites of inflammation. Heparanase also releases heparan sulfate-bound cytokines and chemokines that further promote directed motility and recruitment of immune cells. Heparanase is highly expressed in a vari

SUBMITTER: Tang L 

PROVIDER: S-EPMC8248549 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature