9-Gene Signature Correlated With CD8⁺ T Cell Infiltration Activated by IFN-γ: A Biomarker of Immune Checkpoint Therapy Response in Melanoma.

ABSTRACT:

Purpose

To identify CD8⁺ T cell-related factors and the co-expression network in melanoma and illustrate the interactions among CD8⁺ T cell-related genes in the melanoma tumor microenvironment.

Method

We obtained melanoma and paracancerous tissue mRNA matrices from TCGA-SKCM and GSE65904. The CIBERSORT algorithm was used to assess CD8⁺ T cell proportions, and the "estimate" package was used to assess melanoma tumor microenvironment purity. Weighted gene co-expression network analysis was used to identify the most related co-expression modules in TCGA-SKCM and GSE65904. Subsequently, a co-expression network was built based on the joint results in the two cohorts. Subsequently, we identified the core genes of the two most relevant modules of CD

SUBMITTER: Yan K 

PROVIDER: S-EPMC8248551 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature