Helminth infection induces non-functional sensitization to house dust mites.

ABSTRACT:

Background

IgE characterizes the humoral response of allergic sensitization but less is known about what modulates its function and why some patients present clinical symptoms for a given IgE level and others do not. An IgE response also occurs during helminth diseases, independently of allergic symptoms. This response could be a model of non-functional IgE.

Objective

To study the IgE response against environmental allergens induced during natural helminth infection.

Methods

In 28 non allergic subjects from the periphery of Ho Chi Minh city with (H+, n = 18) and without helminth infection (H-, n = 10), we measured IgE and IgG4 against several components of Dermatophagoïdes pteronyssinus (Dpt) and Ascaris (a marker of immunization against nematodes), and determined the

SUBMITTER: Doyen V 

PROVIDER: S-EPMC8248592 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature