An evolution-based high-fidelity method of epistasis measurement: Theory and application to influenza.

ABSTRACT: Linkage effects in a multi-locus population strongly influence its evolution. The models based on the traveling wave approach enable us to predict the average speed of evolution and the statistics of phylogeny. However, predicting statistically the evolution of specific sites and pairs of sites in the multi-locus context remains a mathematical challenge. In particular, the effects of epistasis, the interaction of gene regions contributing to phenotype, is difficult to predict theoretically and detect experimentally in sequence data. A large number of false-positive interactions arises from stochastic linkage effects and indirect interactions, which mask true epistatic interactions. Here we develop a proof-of-principle method to filter out false-positive interactions. We start by demonstrat

SUBMITTER: Pedruzzi G 

PROVIDER: S-EPMC8248644 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature