Geographic variation in Alzheimer's disease mortality.

ABSTRACT:

Objective

Accumulating evidence suggests the possibility that early life exposures may contribute to risk of Alzheimer's Disease (AD). This paper explores geographic disparities in AD mortality based on both state of residence in older age as well as state of birth measures in order to assess the relative importance of these factors.

Methods

We use a subset of a large survey, the NIH-AARP Diet and Health Study, of over 150,000 individuals aged 65-70 with 15 years of mortality follow-up, allowing us to study over 1050 cases of AD mortality. We use multi-level logistic regression, where individuals are nested within states of residence and/or states of birth, to assess the contributions of place to AD mortality variation.

Results

We show that state of birth explains a m

SUBMITTER: Topping M 

PROVIDER: S-EPMC8248693 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature