Complement Decay-Accelerating Factor is a modulator of influenza A virus lung immunopathology.

ABSTRACT: Clearance of viral infections, such as SARS-CoV-2 and influenza A virus (IAV), must be fine-tuned to eliminate the pathogen without causing immunopathology. As such, an aggressive initial innate immune response favors the host in contrast to a detrimental prolonged inflammation. The complement pathway bridges innate and adaptive immune system and contributes to the response by directly clearing pathogens or infected cells, as well as recruiting proinflammatory immune cells and regulating inflammation. However, the impact of modulating complement activation in viral infections is still unclear. In this work, we targeted the complement decay-accelerating factor (DAF/CD55), a surface protein that protects cells from non-specific complement attack, and analyzed its role in IAV infections. We f

SUBMITTER: Santos NB 

PROVIDER: S-EPMC8248730 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature