Time course of coronary flow capacity impairment in ST-segment elevation myocardial infarction.

ABSTRACT:

Background

Microvascular dysfunction in the setting of ST-elevated myocardial infarction (STEMI) plays an important role in long-term poor clinical outcome. Coronary flow reserve (CFR) is a well-established physiological parameter to interrogate the coronary microcirculation. Together with hyperaemic average peak flow velocity, CFR constitutes the coronary flow capacity (CFC), a validated risk stratification tool in ischaemic heart disease with significant prognostic value. This mechanistic study aims to elucidate the time course of the microcirculation as reflected by alterations in microcirculatory physiological parameters in the acute phase and during follow-up in STEMI patients.

Methods

We assessed CFR and CFC in the culprit and non-culprit vessel in consecutive STEMI pa

SUBMITTER: van Lavieren MA 

PROVIDER: S-EPMC8248849 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature