Easy-HLA: a validated web application suite to reveal the full details of HLA typing.

ABSTRACT:

Motivation

The HLA system plays a pivotal role in both clinical applications and immunology research. Typing HLA genes in patient and donor is indeed required in hematopoietic stem cell and solid-organ transplantation, and the histocompatibility complex region exhibits countless genetic associations with immune-related pathologies. Since the discovery of HLA antigens, the HLA system nomenclature and typing methods have constantly evolved, which leads to difficulties in using data generated with older methodologies.

Results

Here, we present Easy-HLA, a web-based software suite designed to facilitate analysis and gain knowledge from HLA typing, regardless of nomenclature or typing method. Easy-HLA implements a computational and statistical method of HLA haplotypes inference ba

SUBMITTER: Geffard E 

PROVIDER: S-EPMC8248894 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature