Correlation between ketones and mental fatigue in high fat-induced obese and non-obese rats.

ABSTRACT: Obesity, often caused by a diet high in calories and low physical activity, may induce physical fatigue, as experienced via decreased locomotor activity and mental fatigue such as impaired cognition. This study aims to evaluate glucose and ketone levels secondary to high-fat diet (HFD) exposure and signs of physical and mental fatigue. Fifty-four 7-week-old male Sprague Dawley rats (Rattus norvegicus) were assigned to either an HFD (n = 28) or a standard diet (SD; n = 26) for a 6-week period during which body weight, blood glucose, and ketones were measured twice per week. An open field (OF) paradigm was used to measure locomotor activity, while novel object recognition (NOR) test was used as an indicator of cognition. Animals in the HFD group weighed more than SD rats (8.4 g; p < 0.05) st

SUBMITTER: Niepoetter P 

PROVIDER: S-EPMC8248918 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature