Serum uromodulin is inversely associated with biomarkers of subclinical inflammation in the population-based KORA F4 study.

ABSTRACT:

Background

Uromodulin is a kidney-specific glycoprotein synthesized in tubular cells of Henle's loop exerting nephroprotective and immunomodulatory functions in the urinary tract. A small amount of uromodulin is also released into the systemic circulation, where its physiological role is unknown. Serum uromodulin (sUmod) has been associated with metabolic risk factors and with cardiovascular events and mortality, where these associations were partly stronger in men than in women. In this study, we investigated the associations of sUmod with biomarkers of subclinical inflammation in a population-based sample of women and men.

Methods

Associations of sUmod with 10 biomarkers of subclinical inflammation were assessed in 1065 participants of the Cooperative Health Research in th

SUBMITTER: Then C 

PROVIDER: S-EPMC8248959 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature