Recommended Definitions of Aggressive Prostate Cancer for Etiologic Epidemiologic Research.

ABSTRACT:

Background

In the era of widespread prostate-specific antigen testing, it is important to focus etiologic research on the outcome of aggressive prostate cancer, but studies have defined this outcome differently. We aimed to develop an evidence-based consensus definition of aggressive prostate cancer using clinical features at diagnosis for etiologic epidemiologic research.

Methods

Among prostate cancer cases diagnosed in 2007 in the National Cancer Institute's Surveillance, Epidemiology, and End Results-18 database with follow-up through 2017, we compared the performance of categorizations of aggressive prostate cancer in discriminating fatal prostate cancer within 10 years of diagnosis, placing the most emphasis on sensitivity and positive predictive value (PPV).

Results

SUBMITTER: Hurwitz LM 

PROVIDER: S-EPMC8248961 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature